Stage A→C closed on IBM Heron r2 · ibm_marrakesh: same-day full pass.
Raw junction gap 0.185 · Aer retention 0.749 ·
separable contrast 0.184.
Locked junction_ryy · 156 qubits · jobs d9qubi7pemts73crsa2g+.
Classical methods on the same frozen table already disagree. QPC keeps those logics co-resident and returns a measured architecture scorecard with public IBM job IDs.
Public WOW article →
In early drug discovery a molecule is judged by many ADMET properties at once: a multi-logic landscape. Those properties pull in different directions. Classical practice weights them into one number, or applies hard filters one after another. This job puts those logics together inside one auditable quantum run on real hardware.
Freeze a public-proxy desirability table (9 compounds × 17 TDC-aligned ADMET endpoints), encode it as a polycontextural landscape
(9 × 17 data qubits + absorb / clear / safety junctions = 156 qubits), run coupled vs no_cross control under locked
junction_ryy geometry on IBM Heron r2 · ibm_marrakesh, and read a provisional lead ranking from the coupled arm, compared with classical baselines on the same numbers.
Pharma teams already live with multi-objective ADMET conflict (permeability vs toxicity, CNS exposure vs CYP liability, oral absorption vs DILI risk). This exemplar is a bounded, public instance of multi-logic decisioning with IBM job IDs: the shape of an Exemplar Replay a partner can later fill with their own scores under the same schema.
A bounded, public multi-logic ADMET architecture run: frozen public-proxy desirabilities, locked
junction_ryy geometry, coupled vs control vs separable arms, raw junction scorecard, and IBM job IDs.
A partner can fill the same schema with their own scores. See the database page for the frozen table and provenance.
no_cross). Resilience / SAR is a labelled diagnostic channel on the same job.(1) Classical methods disagree on this table: that is why multi-logic architecture matters. (2) Stage C2 on IBM Heron r2 · ibm_marrakesh cleared every pre-registered bar the same day. That is the WOW closure.
| Rank | Compound | Class | Lead score |
|---|---|---|---|
| 1 | caffeine | cns_tool | 0.736 |
| 2 | acetaminophen | analgesic | 0.669 |
| 3 | propranolol | cardiovascular | 0.588 |
| 4 | ibuprofen | nsaid | 0.572 |
| 5 | fluoxetine | cns | 0.568 |
| 6 | terfenadine | withdrawn | 0.567 |
| 7 | digoxin | cardiovascular | 0.530 |
| 8 | cisplatin | oncology | 0.432 |
| 9 | doxorubicin | oncology | 0.343 |
Reading this: favorable oral / CNS-friendly profiles rise; high-toxicity oncology agents fall. A consistent encoding readout of the multi-ADMET landscape on the frozen public-proxy table.
Equal-weight sum ranks: caffeine, acetaminophen, propranolol, ibuprofen, fluoxetine, digoxin, terfenadine, cisplatin, doxorubicin.
Sequential hard filters (hERG, Ames, DILI, P-gp, bioavailability gates) keep: caffeine, propranolol, ibuprofen, fluoxetine. Acetaminophen (weighted-sum #2) drops at the DILI gate. Same table, different classical verdict.
Pareto front (maximize all 17): caffeine, fluoxetine, acetaminophen. Kendall tau (weighted-sum vs sequential) = 0.50: measured disagreement among classical methods.
Hardware ranking order differs from classical equal-weight in places. That difference is an architecture signal on the same table, read together with the raw junction scorecard.
no_cross:
gap 0.185 · retention 0.749 · separable contrast 0.184.
Jobs d9qubi7pemts73crsa2g+ / separable d9qubk8pdb6s73e45q3g.
Primary metrics on raw counts. IBM Heron r2 · ibm_fez Stage B (raw gap ~0.18) is supporting evidence on the same desk family.
Public article: QPC_ADMET_WOW_ARTICLE.html.
Joint multi-logic ADMET decisioning under a published conflict table; co-resident logics in one coherent quantum job; raw junction architecture metrics; Exemplar Replay schema; IBM audit trail.
Frozen score table and column definitions: ADMET_LEAD_DATABASE.html