Kinase Selectivity 9×17 · IBM Heron r2

What the case is

A chemist reading a public kinase map: nine named inhibitors, seventeen kinases. The tension is selectivity versus promiscuity. Intended hits, collateral hits, and safety kinases co-reside in one job.

Goal

Verify KIN-SEL-E1 on raw coupled lead (imatinib > dasatinib) and KIN-SEL-A1 (raw junction gap ≥ 0.05). Flat potency average prefers dasatinib. Sequential spare-safety prefers imatinib.

How it was prepared

Frozen Davis 2011 Kd matrix. One complete source. Nine inhibitors × seventeen kinases.
Three co-resident junctions: intended, collateral, safety.
Expectation locked before IBM submit. 156-qubit desk (9×17 + 3 junctions). junction_ryy, no-cross control.

How it was computed

IBM Heron r2 · ibm_kingston · 4096 shots · job da632keaa69c739lgpag. Transjunctions computed on the QPU. Primary readout: raw counts. Resilience is a labelled diagnostic channel on the same job.

How it was evaluated

PASS when both locked gates hold on the raw QPC readout. Full-panel ranks are reported. The industry finding is the pair, plus the architecture gap.

PASS

E1 + A1

0.610

imatinib

0.547

dasatinib

0.197

raw gap

sunitinib

0.654

gefitinib

0.648

lapatinib

0.647

imatinib

0.610

erlotinib

0.592

sorafenib

0.585

nilotinib

0.583

dasatinib

0.547

midostaurin

0.543

Method	Order on the pair
Equal-weight potency	dasatinib > imatinib
Sequential spare-safety	imatinib > dasatinib
QPC coupled raw	imatinib > dasatinib · PASS

Full kinase report Atlas